Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation

被引：56

作者：

Kaddar, T. ^{[2
]}

Chien, W. W. ^{[2
]}

Bertrand, Y. ^{[3
]}

Pages, M. P. ^{[1
]}

Rouault, J. P. ^{[4
]}

Salles, G. ^{[2
]}

Ffrench, M. ^{[1
,2
]}

Magaud, J. P. ^{[1
,2
]}

机构：

[1] Hosp Civil Lyon, Lab Hematol Lyon, CHLS, F-69495 Pierre Benite, France

[2] Univ Lyon 1, Fac Med Lyon Sud, CNRS, UMR5239,LBMC,IFR128, F-69495 Pierre Benite, France

[3] Inst Hematol & Oncol Pediat, Lyon, France

[4] ENS, UCBL, INRA, CNRS,IGFL,UMR 5242, Lyon, France

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 09期

关键词：

miR-16; Acute lymphoblastic leukemia; Prognosis; Lymphocyte stimulation; targets; MICRORNA EXPRESSION; REGULATORY PROTEINS; SMALL RNAS; CELL; P16(INK4A); OVEREXPRESSION; TRANSCRIPTS; PROFILES; CLUSTER; P53;

D O I：

10.1016/j.leukres.2008.12.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

miR-16, a miRNA involved in cell proliferation and apoptosis regulation, may interfere with either oncogenic or tumor-suppressor pathways and is implicated in leukemogenesis. We then explored its expression in 93 childhood acute lymphoblastic leukemia (ALL) cases. A high miR-16 expression was associated with hyperleukocytosis and poor cytogenetic groups. In the whole group and in B-cell ALLs, disease-free survival (DFS) was significantly shorter for miR-16 above quartile 75. In T-cell ALLs for both DFS and overall survival, a significant trend was found with a survival shortening from the lowest to the highest miR-16 levels. miR-16 expression neither significantly correlated with normal and malignant lymphocyte proliferation nor varied according to lymphocyte differentiation. The prognostic value of miR-16 in childhood ALL highlighted the complexity of miR-16 functions. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1217 / 1223

页数：7

共 37 条

[1]

AJCHENBAUM F, 1993, J BIOL CHEM, V268, P4113

[2]

microRNAs: Tiny regulators with great potential [J].

Ambros, V .

CELL, 2001, 107 (07) :823-826

[3]

MicroRNAs and chromosomal abnormalities in cancer cells [J].

Calin, G. A. ;

Croce, C. M. .

ONCOGENE, 2006, 25 (46) :6202-6210

[4]

Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[5]

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia [J].

Calin, GA ;

Ferracin, M ;

Cimmino, A ;

Di Leva, G ;

Shimizu, M ;

Wojcik, SE ;

Iorio, MV ;

Visone, R ;

Sever, NI ;

Fabbri, M ;

Iuliano, R ;

Palumbo, T ;

Pichiorri, F ;

Roldo, C ;

Garzon, R ;

Sevignani, C ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1793-1801

[6]

MiR-15a and miR-16-1 cluster functions in human leukemia [J].

Calin, George A. ;

Cimmino, Amelia ;

Fabbri, Muller ;

Ferracin, Manuela ;

Wojcik, Sylwia E. ;

Shimizu, Masayoshi ;

Taccioli, Cristian ;

Zanesi, Nicola ;

Garzon, Ramiro ;

Aqeilan, Rami I. ;

Alder, Hansjuerg ;

Volinia, Stefano ;

Rassenti, Laura ;

Liu, Xiuping ;

Liu, Chang-gong ;

Kipps, Thomas J. ;

Negrini, Massimo ;

Croce, Carlo M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (13) :5166-5171

[7]

Widespread microRNA repression by Myc contributes to tumorigenesis [J].

Chang, Tsung-Cheng ;

Yu, Duonan ;

Lee, Yun-Sil ;

Wentzel, Erik A. ;

Arking, Dan E. ;

West, Kristin M. ;

Dang, Chi V. ;

Thomas-Tikhonenko, Andrei ;

Mendell, Joshua T. .

NATURE GENETICS, 2008, 40 (01) :43-50

[8]

Does p16ink4a expression increase with the number of cell doublings in normal and malignant lymphocytes? [J].

Chebel, Amel ;

Chien, Wei-Wen ;

Gerland, Luc-Marie ;

Mekki, Yahia ;

Bertrand, Yves ;

Ffrench, Patrick ;

Galmarini, Carlos Maria ;

Ffrench, Martine .

LEUKEMIA RESEARCH, 2007, 31 (12) :1649-1658

[9]

Real-time quantification of microRNAs by stem-loop RT-PCR [J].

Chen, CF ;

Ridzon, DA ;

Broomer, AJ ;

Zhou, ZH ;

Lee, DH ;

Nguyen, JT ;

Barbisin, M ;

Xu, NL ;

Mahuvakar, VR ;

Andersen, MR ;

Lao, KQ ;

Livak, KJ ;

Guegler, KJ .

NUCLEIC ACIDS RESEARCH, 2005, 33 (20) :e179.1-e179.9

[10]

Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma [J].

Chen, Robert W. ;

Bemis, Lynne T. ;

Amato, Carol M. ;

Myint, Han ;

Tran, Hung ;

Birks, Diane K. ;

Eckhardt, S. Gail ;

Robinson, William A. .

BLOOD, 2008, 112 (03) :822-829

← 1 2 3 4 →