Aromatic allylation via diazotization: Metal-free C-C bond formation

被引：26

作者：

Ek, F

Axelsson, O

Wistrand, LG

Frejd, T

机构：

[1] Lund Univ, Ctr Chem, S-22100 Lund, Sweden

[2] Amersham Hlth R&D AB, Medeon Malmo, S-20512 Malmo, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 18期

关键词：

D O I：

10.1021/jo0258103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of allyl aromatic compounds not involving any metal-containing reagent or catalyst has been developed. Arylamines substituted with a large number of different substituents were converted via diazotizative deamination with tert-butyl nitrite in allyl bromide and acetonitrile to the corresponding allyl aromatic compounds. The allylation reaction was found to be suitable for larger scale synthesis due to short reaction times, a nonextractive workup, and robustness toward moisture, air, and type of solvent.

引用

页码：6376 / 6381

页数：6

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