Catecholamines Regulate Tumor Angiogenesis

被引：157

作者：

Chakroborty, Debanjan ^{[2
]}

Sarkar, Chandrani ^{[2
]}

Basu, Biswarup ^{[1
]}

Dasgupta, Partha Sarathi ^{[1
]}

Basu, Sujit ^{[2
,3
]}

机构：

[1] Chittaranjan Natl Canc Inst, Signal Transduct & Biogen Amines Dept, Kolkata 700026, India

[2] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA

[3] Ohio State Univ, Arthur G James Comprehens Canc Ctr, Columbus, OH 43210 USA

来源：

CANCER RESEARCH | 2009年 / 69卷 / 09期

基金：

美国国家卫生研究院;

关键词：

ENDOTHELIAL GROWTH-FACTOR; OVARIAN-CARCINOMA; BONE-MARROW; PROGENITOR CELLS; DOPAMINE; CANCER; EXPRESSION; NOREPINEPHRINE; METASTASIS; LINES;

D O I：

10.1158/0008-5472.CAN-08-4289

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Among the regulators of angiogenesis, catecholamine neuro-transmitters are of recent interest because of their opposite roles in the regulation of tumor neovascularization. Norepinephrine and epinephrine by acting through specific adrenoceptors increase the synthesis of proangiogenic factors, and thereby, promote tumor growth. In contrast, dopamine acting via its specific D-2 receptors inhibits tumor growth by suppressing the actions of vascular permeability factor/vascular endothelial growth factor-A on both tumor endothelial and bone marrow-derived endothelial progenitor cells. These reports identify novel endogenous regulators of tumor angiogenesis and also indicate a new and an inexpensive class of antiangiogenic drugs for the treatment of cancer. [Cancer Res 2009;69(9):3727-30]

引用

页码：3727 / 3730

页数：4

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