A Questionnaire-Based Survey on the Prescription of Non-Steroidal Anti-Inflammatory Drugs by Physicians in East Asian Countries in 2007

被引：28

作者：

Arakawa, Tetsuo ^{[1
]}

Fujiwara, Yasuhiro ^{[1
]}

Sollano, Jose D. ^{[2
]}

Zhu, Qi ^{[3
,4
]}

Kachintorn, Udom ^{[5
]}

Rani, Abdul Aziz ^{[6
,7
]}

Hahm, Ki-Baik ^{[9
]}

Takahashi, Shin-ichi ^{[13
]}

Joh, Takashi ^{[12
]}

Kinoshita, Yoshikazu ^{[14
]}

Matsumoto, Takayuki ^{[15
]}

Naito, Yuji ^{[11
]}

Takeuchi, Koji ^{[10
]}

Yamagami, Hirokazu ^{[1
]}

Agustanti, Nenny ^{[2
]}

Xiong, Huifang ^{[3
,4
]}

Chen, Xi ^{[3
,4
]}

Jang, Eun Jung ^{[9
]}

Furuta, Kenji ^{[14
]}

Terano, Akira ^{[8
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Gastroenterol, Abeno Ku, Osaka 5458585, Japan

[2] Univ Santo Tomas, Dept Med, Manila, Philippines

[3] Shanghai Med Univ 2, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Rui Jing Hosp, Coll Med, Shanghai 200030, Peoples R China

[5] Mahidol Univ, Siriraj Hosp, Fac Med, Div Gastroenterol,Dept Internal Med, Bangkok 10700, Thailand

[6] Univ Indonesia, Indonesian Univ, Sch Med, Jakarta, Indonesia

[7] Univ Indonesia, Cipto Mangunkusumo Hosp, Fac Med, Dept Internal Med, Jakarta, Indonesia

[8] Dokkyo Med Univ, Mibu, Tochigi, Japan

[9] Jesaeng Hosp Bundang, Daejin Med Ctr, Ctr Digest Dis, Songnam, South Korea

[10] Kyoto Pharmaceut Univ, Dept Pharmacol & Expt Therapeut, Div Pathol Sci, Kyoto 607, Japan

[11] Kyoto Prefectural Univ Med, Dept Mol Gastroenterol & Hepatol, Kyoto, Japan

[12] Nagoya City Univ, Grad Sch Med Sci, Dept Gastroenterol & Metab, Nagoya, Aichi, Japan

[13] Kyorin Univ, Sch Med, Dept Gastroenterol, Kyorin, South Korea

[14] Shimane Univ, Sch Med, Dept Gastroenterol & Hepatol, Izumo, Shimane, Japan

[15] Hyogo Coll Med, Dept Internal Med, Div Lower Gastroenterol, Nishinomiya, Hyogo, Japan

来源：

DIGESTION | 2009年 / 79卷 / 03期

关键词：

Nonsteroidal anti-inflammatory drugs; Aspirin; Cyclooxygenase-2 selective inhibitor; Proton-pump inhibitor; Mucoprotective drug; Helicobacter pylori; HELICOBACTER-PYLORI INFECTION; LOW-DOSE ASPIRIN; GASTROINTESTINAL COMPLICATIONS; CONTROLLED-TRIAL; RISK; METAANALYSIS; ASSOCIATION; INHIBITION; MANAGEMENT; REBAMIPIDE;

D O I：

10.1159/000211713

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are widely used clinically but increase the risk of gastrointestinal (GI) complications. Aim: To examine the current prescription of NSAIDs and comedication to prevent GI complications from NSAIDs within East Asia by means of a questionnaire survey. Methods: Representative members of the Committee of the International Gastrointestinal Consensus Symposium provided a questionnaire to physicians in 6 East Asian countries. Results: A total of 1,568 physicians participated in this survey. Most physicians prescribed nonselective NSAIDs, cyclooxygenase-2 inhibitors (COXIBs) or aspirin for more than 5 patients per week in all countries, with the exception of the prescription of COXIBs in Japan. Of the nonselective NSAIDs, the drug most frequently prescribed as a first choice was loxoprofen (34%), which was mainly prescribed in Japan, followed by diclofenac (30%). The frequency of prescription of comedication with nonselective NSAIDs was higher compared with that for selective COXIBs or aspirin. Physicians in the northern region (China, Japan and Korea) preferred mucoprotective drugs for comedication with NSAIDs or aspirin, while those in southern region (Indonesia, Philippines and Thailand) frequently used proton-pump inhibitors. Conclusion: Among East Asian countries, there are both similarities and differences in the prescription of NSAIDs and of comedication to prevent GI complications. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：177 / 185

页数：9

共 18 条

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