Assessment of Platelet Function on Whole Blood by Multiple Electrode Aggregometry in High-Risk Patients With Coronary Artery Disease Receiving Antiplatelet Therapy

被引：99

作者：

Paniccia, Rita ^{[1
,2
]}

Antonucci, Emilia ^{[2
]}

Maggini, Niccolo ^{[2
]}

Romano, Eloisa ^{[2
]}

Gori, Anna Maria ^{[2
]}

Marcucci, Rossella ^{[2
]}

Prisco, Domenico ^{[2
]}

Abbate, Rosanna ^{[2
]}

机构：

[1] Azienda Osped Univ Careggi, Dip Area Crit Medicochirurg, Ctr Trombosi, Piastra Serv,Dept Heart & Vessels, I-50134 Florence, Italy

[2] Univ Florence, Dept Med & Surg Crit Care, Florence, Italy

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2009年 / 131卷 / 06期

关键词：

Aspirin resistance; Clopidogrel resistance; Coronary syndrome; Light transmission platelet aggregation; Multiplate system; Point-of-care testing; Residual platelet reactivity; Whole blood platelet aggregation; MYOCARDIAL-INFARCTION PATIENTS; ASPIRIN RESPONSIVENESS; MODIFIED THROMBOELASTOGRAPHY; CLOPIDOGREL RESPONSIVENESS; FUNCTION ANALYZER; CARDIAC-SURGERY; FUNCTION TESTS; AGGREGATION; REACTIVITY; RESISTANCE;

D O I：

10.1309/AJCPTE3K1SGAPOIZ

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This study sought to compare Multiplate impedance platelet aggregometry (IPA) with light transmission aggregometry (LTA) and the PFA-100 for determining the prevalence of residual platelet reactivity (RPR) by the Multiplate IPA in 297 patients with acute coronary syndrome receiving dual antiplatelet therapy. Aggregations were induced by adenosine-5 diphosphate (ADP), arachidonic acid, and collagen, PFA-100 closure times were measured by collagen and ADP and epinephrine (CEPI) cartridges. Significant correlations were observed between Multiplate IPA and LTA after all stimulations (P < .0001) and between Multiplate IPA (arachidonate and collagen) and PFA-100 CEPI closure time (P < .0001 for both). Cutoff values of Multiplate IPA (for all stimulations) were calculated for the identification of RPR. Between the Multiplate IPA and LTA good agreement was found with all 3 agonists (P < .0001 for all). Multiplate IPA might represent a reliable, handy, rapid tool for monitor antiplatelet therapy in clinical practice and for clinical investigations.

引用

页码：834 / 842

页数：9

共 44 条

[1] Quantifying the effect of antiplatelet therapy -: A comparison of the platelet function Analyzer (PFA-100®) and modified thromboelastography (mTEG®) with lightt transmission platelet aggregometry [J].