Osteoporosis in elderly: prevention and treatment

被引：287

作者：

Srivastava, M

Deal, C

机构：

[1] Cleveland Clin Fdn, Ctr Osteoporosis & Metabol Bone Dis, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Sect Geriatr Med, Cleveland, OH 44195 USA

来源：

CLINICS IN GERIATRIC MEDICINE | 2002年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0749-0690(02)00022-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

The incidence of osteoporosis increases with advancing age and is a major public health problem in the elderly because of its physical, social and psychological consequences. Osteoporosis and its complications are potentially preventable using non pharmacological and pharmacological methods of treatment. The pharmacological agents currently available act by inhibiting bone resorption, and include hormone replacement therapy, bisphosphonates, calcitonin and Selective Estrogen Receptor Modulators (SERM). Anabolic agents that stimulate bone formation, including PTH, are awaiting approval for use. This article summarizes the epidemiology of osteoporosis in the elderly, the disabilities resulting there from, and then discusses the role of non-pharmacological and pharmacological options for the prevention and treatment of osteoporosis.

引用

收藏

页码：529 / +

页数：28

相关论文

共 122 条

[1]

Ipriflavone in the treatment of postmenopausal osteoporosis - A randomized controlled trial [J].

Alexandersen, P ;

Toussaint, A ;

Christiansen, C ;

Devogelaer, JP ;

Roux, C ;

Fechtenbaum, J ;

Gennari, C ;

Reginster, JY .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (11) :1482-1488

[2]

Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the framingham study [J].

Amin, S ;

Zhang, YQ ;

Sawin, DT ;

Evans, SR ;

Hannan, MT ;

Kiel, DP ;

Wilson, PWF ;

Felson, DT .

ANNALS OF INTERNAL MEDICINE, 2000, 133 (12) :951-963

[3]

Osteoporosis in men [J].

Amin, S ;

Felson, DT .

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2001, 27 (01) :19-+

[4]

Phytoestrogens and bone [J].

Anderson, JJB ;

Garner, SC .

BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1998, 12 (04) :543-557

[5]

The epidemiology of peripheral fractures [J].

Baron, JA ;

Barrett, JA ;

Karagas, MR .

BONE, 1996, 18 (03) :S209-S213

[6]

Low levels of estradiol are associated with vertebral fractures in older men, but not women:: The Rancho Bernardo study [J].

Barrett-Connor, E ;

Mueller, JE ;

Von Mühlen, DG ;

Laughlin, GA ;

Schneider, DL ;

Sartoris, DJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (01) :219-223

[7]

Clinical outcomes and mortality after hip fracture: A 2-year follow-up study [J].

Baudoin, C ;

Fardellone, P ;

Bean, K ;

OstertagEzembe, A ;

Hervy, F .

BONE, 1996, 18 (03) :S149-S157

[8]

Fracture risk reduction with alendronate in women with osteoporosis: The Fracture Intervention Trial [J].

Black, DM ;

Thompson, DE ;

Bauer, DC ;

Ensrud, K ;

Musliner, T ;

Hochberg, MC ;

Nevitt, MC ;

Suryawanshi, S ;

Cummings, SR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (11) :4118-4124

[9]

Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures [J].

Black, DM ;

Cummings, SR ;

Karpf, DB ;

Cauley, JA ;

Thompson, DE ;

Nevitt, MC ;

Bauer, DC ;

Genant, HK ;

Haskell, WL ;

Marcus, R ;

Ott, SM ;

Torner, JC ;

Quandt, SA ;

Reiss, TF ;

Ensrud, KE .

LANCET, 1996, 348 (9041) :1535-1541

[10]

Alendronate and estrogen effects in postmenopausal women with low bone mineral density [J].

Bone, HG ;

Greenspan, SL ;

McKeever, C ;

Bell, N ;

Davidson, M ;

Downs, RW ;

Emkey, R ;

Meunier, PJ ;

Miller, SS ;

Mulloy, AL ;

Recker, RR ;

Weiss, SR ;

Heyden, N ;

Musliner, T ;

Suryawanshi, S ;

Yates, AJ ;

Lombardi, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (02) :720-726

← 1 2 3 4 5 6 7 8 9 10 →