Lignan bis-glucosides from Galium sinaicum

被引:32
作者
ElGamal, AA
Takeya, K
Itokawa, H
Halim, AF
Amer, MM
Saad, HEA
机构
[1] UNIV MANSOURA,FAC PHARM,MANSOURA 35516,EGYPT
[2] TOKYO UNIV PHARM & LIFE SCI,HACHIOJI,TOKYO 19203,JAPAN
关键词
Galium sinaicum; Rubiaceae; roots; lignan glycosides; cytotoxic activity;
D O I
10.1016/S0031-9422(96)00881-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The new lariciresinol-based lignan bis-glucosides, 7S, 8R, 8'R-(-)-lariciresinol-4,4'-bis-O-beta-D-glucopyranoside and 7S, 8R, 8'R-(-)-5-methoxylariciresinol-4,4'-bis- together with (-)syringaresinol-4,4'-bis-O-beta-D-glucopyranside, together with (-)-syringaresinol-4,4'-bis-O-beta-D-glucopyranoside were isolated from the n-butanol extract of Galinum sinaicum roots and their structures were established by various spectroscopic techniques. The isolated compounds represent the first report of lignan glycosides from the Rubiaceae. The two lariciresinol-type glucosides exhibited weak cytotoxic activity against the P388 cell line. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:597 / 600
页数:4
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