Structural revision of shatavarins I and IV, the major components from the roots of Asparagus racemosus

被引：45

作者：

Hayes, Patricia Y. ^{[1
]}

Jahidin, Aisyah Hasyila ^{[1
]}

Lehmann, Reg ^{[1
]}

Penman, Kerry ^{[1
]}

Kitching, William ^{[1
]}

De Voss, James J. ^{[1
]}

机构：

[1] Univ Queensland, Dept Chem, SMMS, Brisbane, Qld 4072, Australia

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 39期

基金：

澳大利亚研究理事会;

关键词：

Asparagus racemosus; shatavarins I and IV; NMR;

D O I：

10.1016/j.tetlet.2006.07.121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The two major steroidal saponins from the roots of Asparagus racemosus were isolated by RP-HPLC and their structure determined by extensive NMR studies. Their structures did not match those reported previously for shatavarins. I and IV and were found to be 3-O-{[beta-D-glueopyranosy](1 -> 2)][alpha-L-rhamnopyranosyl(1 -> 4)]-beta-D-glucopyranosyl}-26-O-(P-D-glu(opyranosyl)-(25S)5 beta-furostan-3p,22 alpha,26-triol and 3-O-{[beta-D-glueopyranosyl(1 -> 2)][alpha-L-rhamnopyranosyl(1 -> 4)]-beta-D-glucopyrariosyl}-(25S)-5 beta-spirostan-3 beta-ol. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6965 / 6969

页数：5

共 19 条

[1] Dependence of the 1H NMR chemical shifts of ring F resonances on the orientation of the 27-methyl group of spirostane-type steroidal sapogenins [J].

Agrawal, PK ;

Bunsawansong, P ;

Morris, GA .

PHYTOCHEMISTRY, 1998, 47 (02) :255-257

[2]

CAPASSO F, 2003, PHTYOTHERAPY QUICK R

[3]

CHIBBER R, 2005, Patent No. 2005060977

[4] Asparosides A and B, two new steroidal saponins from Asparagus meioclados [J].

Feng, J ;

Chen, DF ;

Sun, QZ ;

Nakamura, N ;

Hattori, M .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2002, 4 (03) :221-226

[5]

Goyal R K, 2003, Indian J Med Sci, V57, P408

[6]

HANDA SS, 2003, Patent No. 2003080067

[7] Steroidal saponins from roots of Asparagus officinalis [J].

Huang, XF ;

Kong, LY .

STEROIDS, 2006, 71 (02) :171-176

[8]

JOSHI J, 1988, INDIAN J CHEM B, V27, P12

[9] Steroidal saponins from the fruits of Asparagus racemosus [J].

Mandal, Debayan ;

Banerjee, Sukdeb ;

Mondal, Nirup B. ;

Chakravarty, Ajit K. ;

Sahu, Niranjan P. .

PHYTOCHEMISTRY, 2006, 67 (13) :1316-1321

[10] STRUCTURE ELUCIDATION OF A SPIROSTANOL GLYCOSIDE FROM ASPARAGUS-OFFICINALIS FRUITS BY CONCERTED USE OF TWO-DIMENSIONAL NMR TECHNIQUES [J].

PANT, G ;

PANWAR, MS ;

NEGI, DS ;

RAWAT, MSM ;

MORRIS, GA ;

THOMPSON, RIG .

MAGNETIC RESONANCE IN CHEMISTRY, 1988, 26 (10) :911-918

← 1 2 →