Important differences between topoisomerase-I and -II targeting agents

被引:11
作者
Banerji, Shantanu [1 ]
Los, Marek [1 ]
机构
[1] Manitoba Inst Cell Biol, Canada Res Chair Canc Therapy Dev, Winnipeg, MB R3E 0V9, Canada
关键词
mitoxantrone; topotecan; topoisomerase targeting agents; reactive oxygen species (ROS); X2HS;
D O I
10.4161/cbt.5.8.3274
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:965 / 966
页数:2
相关论文
共 20 条
[1]   Guiding ATM to broken DNA [J].
Abraham, RT ;
Tibbetts, RS .
SCIENCE, 2005, 308 (5721) :510-511
[2]  
Banáth JP, 2003, CANCER RES, V63, P4347
[3]  
Burma S, 2001, J BIOL CHEM, V276, P42462, DOI 10.1074/jbc.C100466200
[4]  
DOROSHOW JH, 2006, CANC CHEMOTHERAPY BI
[5]  
HSIANG YH, 1988, CANCER RES, V48, P1722
[6]  
HSIANG YH, 1989, CANCER RES, V49, P5077
[7]  
HSIANG YH, 1985, J BIOL CHEM, V260, P4873
[8]   Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine [J].
Huang, Xuan ;
Kurose, Akira ;
Tanaka, Toshiki ;
Traganos, Frank ;
Dai, Wei ;
Darzynkiewicz, Zbigniew .
CANCER BIOLOGY & THERAPY, 2006, 5 (08) :959-964
[9]   Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species [J].
Kurz, EU ;
Douglas, P ;
Lees-Miller, SP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (51) :53272-53281
[10]   Reactive oxygen species elicit apoptosis by concurrently disrupting topoisomerase II and DNA-dependent protein kinase [J].
Lu, HR ;
Zhu, H ;
Huang, M ;
Chen, Y ;
Cai, YJ ;
Miao, ZH ;
Zhang, JS ;
Ding, J .
MOLECULAR PHARMACOLOGY, 2005, 68 (04) :983-994