Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells

被引：45

作者：

Göke, R ^{[1
]}

Gregel, C ^{[1
]}

Göke, A ^{[1
]}

Arnold, R ^{[1
]}

Schmidt, H ^{[1
]}

Lankat-Buttgereit, B ^{[1
]}

机构：

[1] Univ Marburg, Clin Res Unit Gastrointestinal Endocrinol, Marburg, Germany

来源：

GASTROENTEROPANCREATIC NEUROENDOCRINE TUMOR DISEASE: MOLECULAR AND CELL BIOLOGICAL ASPECTS | 2004年 / 1014卷

关键词：

PDCD4; carbonic anhydrase; carcinoid; neuroendocrine tumor;

D O I：

10.1196/annals.1294.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PDCD4 is a new tumor suppressor gene. :In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation. This is most likely caused by a PDCD4-induced downregulation of carbonic anhydrase type II which catalyzes the production of bicarbonate, a fundamental substrate for many cellular pathways.

引用

页码：220 / 221

页数：2