Anti-beta 2 glycoprotein I antibodies in a general obstetric population: Preliminary results on the prevalence and correlation with pregnancy outcome. Anti-beta 2 glycoprotein I antibodies are associated with some obstetrical complications, mainly preeclampsia-eclampsia

被引：72

作者：

Faden, D ^{[1
]}

Tincani, A ^{[1
]}

Tanzi, P ^{[1
]}

Spatola, L ^{[1
]}

Lojacono, A ^{[1
]}

Tarantini, M ^{[1
]}

Balestrieri, G ^{[1
]}

机构：

[1] UNIV BRESCIA,CLIN IMMUNOL UNIT,I-25100 BRESCIA,ITALY

来源：

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1997年 / 73卷 / 01期

关键词：

anti-beta 2 glycoprotein I antibodies; antiphospholipid antibodies; pregnancy outcome; preeclampsia; fetal growth retardation;

D O I：

10.1016/S0301-2115(97)02736-X

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To evaluate the prevalence in normal pregnancies of anti-beta 2 glycoprotein I (anti-beta 2GPI) antibodies, and their association with obstetrical complications. Study design: Prospective study of anti-beta 2GPI and anticardiolipin (CL) antibodies in 510 healthy pregnant women at 15-18 weeks. According to the results, women were categorized into three groups: group I, negative for both antibodies; group II, positive for anti-beta 2GPI antibodies; group III, positive for aCL only. The rates of fetal loss, abruptio placentae, preeclampsia-eclampsia. and fetal growth retardation were compared in the three groups. Results: Anti-beta 2GPI antibodies were found in 20 women (3.9%) and aCL in 8 patients (1.6%). Obstetrical complications were more frequent, even if not significantly different, in group IT, 15%, than in group I, 4.1% (difference 10.9%; 95% confidence interval (CI): 1.6-20.2%; p=0.0575), while no complications were seen in group III. Preeclampsia-eclampsia were significantly more frequent in group TI (10%) than in group I (0.8%; difference 9.2%; 95% CI: 4.4-14%; p=0.021). The prevalence of fetal growth retardation was not significantly different in the two groups (5% vs. 2%, respectively). Comment: Our findings indicate that anti-beta 2GPI antibodies are associated with some obstetrical complications, mainly preeclampsia-eclampsia, even if more conventional antiphospholipid antibodies are not present. This observation suggests that these antibodies should be investigated in such cases, in order to improve the outcome of subsequent pregnancies, as well as in women with a history of early and/or recurrent severe preeclampsia in order to start a prophylactic treatment (i.e. low-dose aspirin or heparin). (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：37 / 42

页数：6

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