Therapeutic Implications of the Cancer Stem Cell Hypothesis

被引：107

作者：

Diehn, Maximilian ^{[1
,4
,5
]}

Cho, Robert W. ^{[2
,4
,5
]}

Clarke, Michael F. ^{[2
,3
]}

机构：

[1] Stanford Univ, Dept Radiat Oncol, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Pediat, Sch Med, Div Stem Cell Transplantat, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

[4] Stanford Univ, Ludwig Ctr Stanford, Sch Med, Stanford, CA 94305 USA

[5] Stanford Univ, Stanford Canc Ctr, Sch Med, Stanford Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

来源：

SEMINARS IN RADIATION ONCOLOGY | 2009年 / 19卷 / 02期

关键词：

FUNCTIONAL MAMMARY-GLAND; TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; SIDE POPULATION; COLON-CANCER; PROSPECTIVE IDENTIFICATION; PANCREATIC-CANCER; DRUG-RESISTANCE; PROSTATE-CANCER;

D O I：

10.1016/j.semradonc.2008.11.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A growing body of evidence indicates that subpopulations of cancer stem cells (CSCs) drive and maintain many types of human malignancies. These findings have important implications for the development and evaluation of oncologic therapies and present opportunities for potential gains in patient outcome. The existence of CSCs mandates careful analysis and comparison of normal tissue stem cells and CSCs to identify differences between the two cell types. The development of CSC-targeted treatments will face a number of potential hurdles, including normal stem cell toxicity and the acquisition of treatment resistance, which must be considered in order to maximize the chance that such therapies will be successful. Semin Radiat Oncol 19:78-86 (C) 2009 Elsevier Inc. All rights reserved.

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页码：78 / 86

页数：9

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