Cell-cycle control: POLO-like kinases join the outer circle

被引:68
作者
Lane, HA [1 ]
Nigg, EA [1 ]
机构
[1] UNIV GENEVA, DEPT MOL BIOL, CH-1211 GENEVA, SWITZERLAND
关键词
D O I
10.1016/S0962-8924(96)10051-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Named after the polo gene of Drosophila, POLO-like kinases (PLKs) constitute a novel, evolutionarily conserved family of essential cell-cycle regulators. As emphasized in this review, recent studies identify, important roles for vertebrate PLKs at the onset of mitosis: Plx1, a Xenopus PLK, has been implicated in the activation of Cdc25 phosphatase (and hence the activation of Cdc2) while human Plk1 is required for the proper maturation of the poles of mitotic spindles. These studies suggest a major role for Plk1/Plx1 in coordinating spindle assembly with the activation of Cdc2-cyclin complexes, and they establish a direct link between PLKs and the core cell-cycle-regulatory machinery. Genetic and biochemical studies in yeasts and Drosophila point to additional roles for PLKs at later stages of mitosis. Finally, mammals express multiple PLKs, suggesting that different family members might function at distinct cell-cycle transitions, reminiscent of cyclin-dependent kinases.
引用
收藏
页码:63 / 68
页数:6
相关论文
共 51 条
  • [1] BRAUNINGER A, 1995, ONCOGENE, V11, P1793
  • [2] DUPLICATION OF SPINDLE PLAQUES AND INTEGRATION OF YEAST-CELL CYCLE
    BYERS, B
    GOETSCH, L
    [J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1973, 38 : 123 - 131
  • [3] IDENTIFICATION AND CLONING OF A PROTEIN KINASE-ENCODING MOUSE GENE, PLK, RELATED TO THE POLO GENE OF DROSOPHILA
    CLAY, FJ
    MCEWEN, SJ
    BERTONCELLO, I
    WILKS, AF
    DUNN, AR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) : 4882 - 4886
  • [4] IDENTIFICATION BY TARGETED DIFFERENTIAL DISPLAY OF AN IMMEDIATE-EARLY GENE ENCODING A PUTATIVE SERINE/THREONINE KINASE
    DONOHUE, PJ
    ALBERTS, GF
    GUO, Y
    WINKLES, JA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (17) : 10351 - 10357
  • [5] A CONSERVED MITOTIC KINASE ACTIVE AT LATE ANAPHASE TELOPHASE IN SYNCYTIAL DROSOPHILA EMBRYOS
    FENTON, B
    GLOVER, DM
    [J]. NATURE, 1993, 363 (6430) : 637 - 640
  • [6] SAK, A MURINE PROTEIN-SERINE/THREONINE KINASE THAT IS RELATED TO THE DROSOPHILA-POLO KINASE AND INVOLVED IN CELL-PROLIFERATION
    FODE, C
    MOTRO, B
    YOUSEFI, S
    HEFFERNAN, M
    DENNIS, JW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) : 6388 - 6392
  • [7] Fode C, 1996, MOL CELL BIOL, V16, P4665
  • [8] CDC25 IS A SPECIFIC TYROSINE PHOSPHATASE THAT DIRECTLY ACTIVATES P34CDC2
    GAUTIER, J
    SOLOMON, MJ
    BOOHER, RN
    BAZAN, JF
    KIRSCHNER, MW
    [J]. CELL, 1991, 67 (01) : 197 - 211
  • [9] Golsteyn R M, 1996, Prog Cell Cycle Res, V2, P107
  • [10] CELL-CYCLE REGULATION OF THE ACTIVITY AND SUBCELLULAR-LOCALIZATION OF PLK1, A HUMAN PROTEIN-KINASE IMPLICATED IN MITOTIC SPINDLE FUNCTION
    GOLSTEYN, RM
    MUNDT, KE
    FRY, AM
    NIGG, EA
    [J]. JOURNAL OF CELL BIOLOGY, 1995, 129 (06) : 1617 - 1628