A new class of chiral pyrrolidine-pyridine conjugate base catalysts for use in asymmetric Michael addition reactions

被引：375

作者：

Ishii, T ^{[1
]}

Fujioka, S ^{[1
]}

Sekiguchi, Y ^{[1
]}

Kotsuki, H ^{[1
]}

机构：

[1] Kochi Univ, Fac Sci, Lab Nat Prod Synth, Kochi 7808520, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 31期

关键词：

D O I：

10.1021/ja046871g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Direct catalytic asymmetric Michael addition reactions of ketones to nitroolefins using newly developed chiral pyrrolidine-pyridine conjugate bases as catalysts are described. The desired 1,4-adducts are obtained in excellent yields with high enantio- and diastereoselectivities. Copyright © 2004 American Chemical Society.

引用

页码：9558 / 9559

页数：2

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