The value of risk-factor ("black-box") epidemiology

被引：69

作者：

Greenland, S ^{[1
]}

Gago-Dominguez, M

Castelao, JE

机构：

[1] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Stat, Los Angeles, CA 90095 USA

[3] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA USA

来源：

EPIDEMIOLOGY | 2004年 / 15卷 / 05期

关键词：

D O I：

10.1097/01.ede.0000134867.12896.23

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Risk-factor epidemiology has been denigrated by some as an empty search for associations, unguided by underlying theory. It has been defended for occasionally identifying useful (if poorly understood) potential interventions. We further defend risk-factor epidemiology as a valuable source of seemingly unrelated facts that await coherent explanation by novel theories and that provide empiric tests of theories. We illustrate these points with a theory that invokes lipid peroxidation as an explanation of an apparently incoherent accumulation of facts about renal-cell carcinoma.(1) The example illustrates the value of viewing epidemiologic, laboratory, and clinical observations as a body of facts demanding explanation by proposed causal theories, whether or not those observations were collected with any hypothesis in mind.

引用

页码：529 / 535

页数：7

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