Association between catechol-O-methyltransferase and phobic anxiety

被引：80

作者：

McGrath, M

Kawachi, I

Ascherio, A

Colditz, GA

Hunter, DJ

De Vivo, I

机构：

[1] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[6] Harvard Univ, Sch Publ Hlth, Dept Hlth & Soc Behav, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2004年 / 161卷 / 09期

关键词：

D O I：

10.1176/appi.ajp.161.9.1703

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The authors assessed the association between the catechol-O-methyltransferase (COMT) Va1158Met polymorphism and scores on the phobic anxiety scale of the Crown-Crisp Experimental Index. Method: A total of 1,234 women completed the Crown-Crisp Experimental Index phobic anxiety scale and were genotyped for the COMT polymorphism. The authors used unconditional logistic regression to compute odds ratios and 95% confidence intervals (CIs) to evaluate the association between the COMT genotype and phobic anxiety. Results: The mean scores for the three genotypes were statistically significantly different. Compared to the COMT Met/Met genotype, the age-adjusted odds ratio for scoring greater than or equal to6 compared to scoring 0 or 1 were 1.15 (95% CI=0.71-1.85) and 1.99 (95% CI=1.17-3.40) for the COMT Val/Met and COMT Val/Val genotypes, respectively; a significant gene dosage effect was observed. Conclusions: Our results suggest that the functional COMT polymorphism is associated with the development of phobic anxiety.

引用

页码：1703 / 1705

页数：3

共 14 条

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