The sea urchin kinoine: A first look

被引:59
作者
Bradham, Cynthia A.
Foltz, Kathy R.
Beane, Wendy S.
Arnone, Maria I.
Rizzo, Francesca
Coffman, James A.
Mushegian, Arcady
Goel, Manisha
Morales, Julia
Geneviere, Anne-Marie
Lapraz, Francois
Robertson, Anthony J.
Kelkar, Femant
Loza-Coll, Mariano
Townley, Ian K.
Raisch, Michael
Roux, Michelle M.
Lepage, Thierry
Gache, Christian
McClay, David R.
Manning, Gerard
机构
[1] Duke Univ, DCMB Grp, Durham, NC 27708 USA
[2] UCSB, Dept Mol Cellular & Dev Biol, Santa Barbara, CA USA
[3] Stn Zool A Dohrn, I-80121 Naples, Italy
[4] Mt Desert Isl Biol Lab, Salsbury Cove, ME USA
[5] Univ Kansas, Med Ctr, Dept Microbiol, Kansas City, KS 66103 USA
[6] Stowers Inst Med Res, Kansas City, MO USA
[7] UPMC, Equipe Cycle Cellulaire & Dev, CNRS, UMR 7150,Stn Biol, Roscoff, France
[8] Univ Paris 06, Observ Ocean Banyuls, Lab Arago, CNRS,UMR7628, Banyuls sur Mer, France
[9] CNRS, Dev Biol Lab, UMR 7009, Villefranche Sur Mer, France
[10] Univ Paris 06, Observ Oceanol, Villefranche Sur Mer, France
[11] Univ N Carolina, Ctr Bioinformat, Program Mol Biol & Biotechnol, Chapel Hill, NC 27515 USA
[12] Univ Toronto, Sunnybrook Res Inst, Toronto, ON, Canada
[13] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
[14] Salk Inst Biol Studies, Razavi Newman Ctr Bioinformat, La Jolla, CA 92037 USA
基金
美国国家卫生研究院;
关键词
kinase; signal transduction; genome; kinome;
D O I
10.1016/j.ydbio.2006.08.074
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy The results show that the sea urchin kinome, consisting of 353 protein kinases, is closer to the Drosophila kinome (239) than the human kinome (518) with respect to total kinase number. However, the diversity of sea urchin kinases is surprisingly similar to humans, since the urchin kinome is missing only 4 of 186 human subfamilies, while Drosophila lacks 24. Thus, the sea urchin kinome combines the simplicity of a non-duplicated genome with the diversity of function and signaling previously considered to be vertebrate-specific. More than half of the sea urchin kinases are involved with signal transduction, and approximately 88% of the signaling kinases are expressed in the developing embryo. These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:180 / 193
页数:14
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