Prednisolone plus albuterol versus albuterol alone in mild to moderate bronchiolitis

被引：45

作者：

Goebel, J ^{[1
]}

Estrada, B ^{[1
]}

Quinonez, J ^{[1
]}

Nagji, N ^{[1
]}

Sanford, D ^{[1
]}

Boerth, RC ^{[1
]}

机构：

[1] Univ S Alabama, Dept Pediat, Mobile, AL 36688 USA

来源：

CLINICAL PEDIATRICS | 2000年 / 39卷 / 04期

关键词：

D O I：

10.1177/000992280003900404

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

To evaluate combination therapy of mild to moderate bronchiolitis with bronchiodilators and corticosteroids, we treated 51 young children with first-time wheezing and symptoms of respiratory tract infection with albuterol plus either prednisolone or placebo for 5 days. Disease severity was scored on days 0, 2, 3, and 6, On day 2, prednisolone resulted in significantly lower scores (2.7 +/- 1.4 vs. 4.0 +/- 1.5 in all patients evaluated, p<0.05) than placebo, whereas there was no detectable difference on day 6, suggesting that addition of prednisolone to albuterol transiently accelerates recovery from bronchiolitis. The clinical significance of this effect needs to be evaluated in further studies.

引用

页码：213 / 220

页数：8

共 28 条

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