Breakpoint characterization of der(9) deletions in chronic myeloid leukemia patients

被引：47

作者：

Storlazzi, CT

Specchia, G

Anelli, L

Albano, F

Pastore, D

Zagaria, A

Rocchi, M

Liso, V

机构：

[1] Univ Bari, DAPEG, Sez Genet, I-70126 Bari, Italy

[2] Univ Bari, Dept Hematol, Bari, Italy

[3] Univ Foggia, Dept Hematol, Foggia, Italy

来源：

GENES CHROMOSOMES & CANCER | 2002年 / 35卷 / 03期

关键词：

D O I：

10.1002/gcc.10116

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Deletions adjacent to the 9/22 translocation breakpoint on the derivative chromosome 9 have recently been described in a substantial number of chronic myeloid leukemia (CML) cases, but their extension has not been characterized in detail. Using FISH with an appropriate set of BAC/PAC probes, we have characterized the deletion in 10 CML cases, identified by screening 71 patients at diagnosis. Five patients showed a complex chromosome rearrangement and 3 of them were deleted. The size of the deletion was variable, ranging from few hundreds kb to 8 Mb. A minimally deleted region on both chromosomes 9 and 22 was identified and was found to contain the ASS gene on chromosome 9 and IGLL1 on chromosome 22. (C) 2002 Wiley-Liss, Inc.

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页码：271 / 276

页数：6

相关论文

共 17 条

[1] ALTERATIONS IN THE P53 GENE AND THE CLONAL EVOLUTION OF THE BLAST CRISIS OF CHRONIC MYELOCYTIC-LEUKEMIA [J].

AHUJA, H ;

BARELI, M ;

ADVANI, SH ;

BENCHIMOL, S ;

CLINE, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (17) :6783-6787

[2] TRANSLOCATION OF C-ABL ONCOGENE CORRELATES WITH THE PRESENCE OF A PHILADELPHIA-CHROMOSOME IN CHRONIC MYELOCYTIC-LEUKEMIA [J].

BARTRAM, CR ;

DEKLEIN, A ;

HAGEMEIJER, A ;

VANAGTHOVEN, T ;

VANKESSEL, AG ;

BOOTSMA, D ;

GROSVELD, G ;

FERGUSONSMITH, MA ;

DAVIES, T ;

STONE, M ;

HEISTERKAMP, N ;

STEPHENSON, JR ;

GROFFEN, J .

NATURE, 1983, 306 (5940) :277-280

[3] Subgroup of patients with Philadelphia-positive chronic myelogenous leukemia characterized by a deletion of 9q proximal to ABL gene:: expression profiling, resistance to interferon therapy, and poor prognosis [J].

Cohen, N ;

Rozenfeld-Granot, G ;

Hardan, I ;

Brok-Simoni, F ;

Amariglio, N ;

Rechavi, G ;

Trakhtenbrot, L .

CANCER GENETICS AND CYTOGENETICS, 2001, 128 (02) :114-119

[4] ABL-BCR expression does not correlate with deletions on the derivative chromosome 9 or survival in chronic myeloid leukemia [J].

de la Fuente, J ;

Merx, K ;

Steer, EJ ;

Müller, M ;

Szydlo, RM ;

Maywald, O ;

Berger, U ;

Hehlmann, R ;

Goldman, JM ;

Cross, NCP ;

Melo, JV ;

Hochhaus, A .

BLOOD, 2001, 98 (09) :2879-2880

[5]

Deininger M W, 1998, Curr Opin Hematol, V5, P302

[6] Mechanisms of disease - The biology of chronic myeloid leukemia [J].

Faderl, S ;

Talpaz, M ;

Estrov, Z ;

O'Brien, S ;

Kurzrock, R ;

Kantarjian, HM .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (03) :164-172

[7] Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia [J].

Huntly, BJP ;

Reid, AG ;

Bench, AJ ;

Campbell, LJ ;

Telford, N ;

Shepherd, P ;

Szer, J ;

Prince, HM ;

Turner, P ;

Grace, C ;

Nacheva, EP ;

Green, AR .

BLOOD, 2001, 98 (06) :1732-1738

[8]

ISCN, 1995, INT SYST HUM CYT NOM

[9] ASSIGNMENT OF THE STRUCTURAL GENE FOR ARGININOSUCCINATE SYNTHETASE TO PROXIMAL MOUSE CHROMOSOME-2 [J].

JACKSON, MJ ;

SURH, LC ;

OBRIEN, WE ;

BEAUDET, AL .

GENOMICS, 1990, 6 (03) :545-547

[10] CHRONIC MYELOGENOUS LEUKEMIA IN BLAST CRISIS - ANALYSIS OF 242 PATIENTS [J].

KANTARJIAN, HM ;

KEATING, MJ ;

TALPAZ, M ;

WALTERS, RS ;

SMITH, TL ;

CORK, A ;

MCCREDIE, KB ;

FREIREICH, EJ .

AMERICAN JOURNAL OF MEDICINE, 1987, 83 (03) :445-454