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Genes and genomes of Necator americanus and related hookworms

被引：31
作者：
Blaxter, M [1 ]
机构：
[1] Univ Edinburgh, ICAPB, Edinburgh EH9 3JT, Midlothian, Scotland
来源：
INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2000年 / 30卷 / 04期
关键词：
Ancylostoma duodenale; Caenorhabditis elegans; EST; genomics; Necator americanus;
D O I：
10.1016/S0020-7519(99)00198-8
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The human hookworms (Necator americanus and Ancylostoma duodenale) infect over one billion people. The phylogenetic relationships of the human hookworms suggest independent acquisition of the human host. The hookworms probably have a haploid chromosome number n = 6. and an XX-XO sex determination mechanism is likely to be used. Genetic and molecular research on hookworms is in its infancy, but several important genes and gene products have already been identified. Of note are cathepsin genes, a family of secreted proteins known as Ancylostoma activation-associated proteins and a family of anticoagulants. The inception of an expressed sequence tag program on the human hookworm, N. americanus, promises to yield many new genes with novel functions in the biology of these important parasites. (C) 2000 Australian Society for Parasitology Inc. Published by Elsevier Science. All rights reserved.
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收藏
页码：347 / 355
页数：9
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