Effect of LY293111 in combination with gemcitabine in colonic cancer

被引：33

作者：

Hennig, R

Ding, XZ

Tong, WG

Witt, RC

Jovanovic, BD

Adrian, TE

机构：

[1] Northwestern Univ, Dept Surg, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CANCER LETTERS | 2004年 / 210卷 / 01期

关键词：

colon cancer; heterotopic xenografts; LY293111; gemcitabine;

D O I：

10.1016/j.canlet.2004.02.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

New adjuvant therapies are needed for the treatment of stage III colon cancer. The essential fatty acids, linoleic and arachidonic acid enhance tumorigenesis through the cyclooxygenase and lipoxygenase pathways. Leukotriene B-4 (LTB4) is a product of 5-lipoxygenase (5-LOX) which has tumor-promoting effects. The LTB4 receptor antagonist, LY293111 inhibited tumor growth and induced apoptosis in vitro. The effectiveness of LY293111, alone and in combination with gemcitabine was investigated in a heterotopic xenograft model in athymic mice using HT29 and LoVo human colonic cancer cells. The combined therapy markedly inhibited tumor growth and could warrant consideration as a new therapeutic option. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：41 / 46

页数：6

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