Molecular Therapies in Hepatocellular Carcinoma: What Can We Target?

被引：60

作者：

Galuppo, Roberto ^{[1
]}

Ramaiah, Dinesh ^{[1
]}

Ponte, Oscar Moreno ^{[1
]}

Gedaly, Roberto ^{[1
]}

机构：

[1] Univ Kentucky, Coll Med, Dept Surg, Div Transplantat Surg, Lexington, KY 40536 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2014年 / 59卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Hepatocellular carcinoma; Sorafenib; Ras/Raf/MAPK; Liver cancer stem cells; Epidermal growth factor; ENDOTHELIAL GROWTH-FACTOR; PROTEIN-KINASE; CELL-GROWTH; CANCER; INHIBITION; SORAFENIB; PATHWAYS; ANGIOGENESIS; COMBINATION; HEPATITIS;

D O I：

10.1007/s10620-014-3058-x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Numerous signaling pathways, such as Ras/Raf/MAPK, have been implicated in hepatic carcinogenesis. There are at least 35 combination therapy studies for advanced stage hepatocellular carcinoma (HCC) ongoing, and numerous reagents are being tested targeting novel signaling cascades. The management of HCC has changed substantially in recent times, and the successful development of sorafenib has prompted further expansion on molecular targeted therapies to potentially inhibit different pathways in hepatocarcinogenesis.

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收藏

页码：1688 / 1697

页数：10

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