Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains

被引：26

作者：

Blizzard, TA ^{[1
]}

DiNinno, F ^{[1
]}

Morgan, JD ^{[1
]}

Wu, JY ^{[1
]}

Chen, HY ^{[1
]}

Kim, S ^{[1
]}

Chan, WD ^{[1
]}

Birzin, ET ^{[1
]}

Yang, YT ^{[1
]}

Pai, LY ^{[1
]}

Zhang, ZP ^{[1
]}

Hayes, EC ^{[1
]}

DaSilva, CA ^{[1
]}

Tang, W ^{[1
]}

Rohrer, SP ^{[1
]}

Schaeffer, JM ^{[1
]}

Hammond, ML ^{[1
]}

机构：

[1] Merck Res Labs, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 15期

关键词：

SERMs; SERAMs; estrogen;

D O I：

10.1016/j.bmcl.2004.05.073

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzoxathiin SERAMs with heteroatom-substituted amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：3865 / 3868

页数：4

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