Updates in Rhea - an expert curated resource of biochemical reactions

被引：37

作者：

Morgat, Anne ^{[1
,2
]}

Lombardot, Thierry ^{[1
]}

Axelsen, Kristian B. ^{[1
]}

Aimo, Lucila ^{[1
]}

Niknejad, Anne ^{[3
]}

Hyka-Nouspikel, Nevila ^{[1
]}

Coudert, Elisabeth ^{[1
]}

Pozzato, Monica ^{[1
]}

Pagni, Marco ^{[3
]}

Moretti, Sebastien ^{[3
,4
]}

Rosanoff, Steven ^{[5
]}

Onwubiko, Joseph ^{[5
]}

Bougueleret, Lydie ^{[1
]}

Xenarios, Ioannis ^{[1
,3
,6
]}

Redaschi, Nicole ^{[1
]}

Bridge, Alan ^{[1
]}

机构：

[1] SIB Swiss Inst Bioinformat, CMU, Swiss Prot Grp, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland

[2] INRIA Grenoble Rhone Alpes, ERABLE Team, 655 Ave Europe, F-38330 Montbonnot St Martin, France

[3] SIB Swiss Inst Bioinformat, Vital IT, Batiment Genopode, CH-1015 Lausanne, Switzerland

[4] Univ Lausanne, Evolutionary Bioinformat Grp, Biophore, Dept Ecol & Evolut, CH-1015 Lausanne, Switzerland

[5] European Mol Biol Lab, European Bioinformat Inst EMBL EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SD, England

[6] Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland

来源：

NUCLEIC ACIDS RESEARCH | 2017年 / 45卷 / D1期

关键词：

ENZYME; TOOL; RECONCILIATION; METABOLITES; COLLECTION; EXPRESSION; DATABASE; GENE;

D O I：

10.1093/nar/gkw990

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Rhea (http://www.rhea-db.org) is a comprehensive and non-redundant resource of expert-curated biochemical reactions designed for the functional annotation of enzymes and the description of metabolic networks. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions, using entities from the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules. Here we describe developments in Rhea since our last report in the database issue of Nucleic Acids Research. These include the first implementation of a simple hierarchical classification of reactions, improved coverage of the IUBMB Enzyme Nomenclature list and additional reactions through continuing expert curation, and the development of a new website to serve this improved dataset.

引用

页码：D415 / D418

页数：4

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