3,5-nonadiyne isolated from the rhizome of Cachrys ferulacea inhibits endogenous nitric oxide release by rat peritoneal macrophages

被引：33

作者：

Dokovic, DD

Bulatovic, VM

Bozic, BD

Kataranovski, MV

Zrakic, TM

Kovacevic, NN

机构：

[1] Univ Belgrade, Fac Chem, Belgrade, Serbia

[2] Inst Med Plant Res Dr Josif Pancic, Belgrade, Serbia

[3] Univ Belgrade, Fac Biol, Belgrade, Serbia

[4] Mil Med Acad, Inst Med Res, YU-11002 Belgrade, Serbia

[5] Fac Pharm Belgrade, Belgrade, Serbia

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 07期

关键词：

3,5-nonadiyne; Cachrys ferulacea; Prangos ferulacea; endogenous nitric oxide; inhibition;

D O I：

10.1248/cpb.52.853

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC50=6.7 +/- 0.8 mum) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously.

引用

页码：853 / 854

页数：2

共 14 条

[1]

Baser K. H. C., 1996, Journal of Essential Oil Research, V8, P297

[2]

A new bisabolene derivative from the essential oil of Prangos uechtritzii fruits [J].