Inhibit GSK-3β or there's heartbreak dead ahead

被引：35

作者：

Murphy, E ^{[1
]}

机构：

[1] NIEHS, Lab Signal Transduct, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 11期

关键词：

D O I：

10.1172/JCI200421986

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Numerous signaling pathways have been shown to mediate cardioprotection, but the end effectors that mediate protection are only beginning to be elucidated. Numerous cardioprotective drugs are shown to converge on glycogen synthase kinase-3beta (GSK-3beta) (see the related article beginning on page 1535). The phosphorylation and inhibition of GSK-3beta lead to inhibition or delayed activation of the mitochondrial permeability transition, a key regulator of apoptosis.

引用

页码：1526 / 1528

页数：3

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