Central role of peroxisomes in isoprenoid biosynthesis

被引：117

作者：

Kovacs, WJ ^{[1
]}

Olivier, LM ^{[1
]}

Krisans, SK ^{[1
]}

机构：

[1] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA

来源：

PROGRESS IN LIPID RESEARCH | 2002年 / 41卷 / 05期

关键词：

D O I：

10.1016/S0163-7827(02)00002-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxisomes contain enzymes catalyzing a number of indispensable metabolic functions mainly related to lipid metabolism. The importance of peroxisomes in man is stressed by the existence of genetic disorders in which the biogenesis of the organelle is defective, leading to complex developmental and metabolic phenotypes. The purpose of this review is to emphasize some of the recent findings related to the localization of cholesterol biosynthetic enzymes in peroxisomes and to discuss the impairment of cholesterol biosynthesis in peroxisomal deficiency diseases. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：369 / 391

页数：23

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