Mechanisms of the intestinal effects of dietary fats and milk products on colon carcinogenesis

被引：57

作者：

VanderMeer, R ^{[1
]}

Lapre, JA ^{[1
]}

Govers, MJAP ^{[1
]}

Kleibeuker, JH ^{[1
]}

机构：

[1] UNIV GRONINGEN HOSP, DEPT GASTROENTEROL, GRONINGEN, NETHERLANDS

来源：

CANCER LETTERS | 1997年 / 114卷 / 1-2期

关键词：

colon cancer; hyperproliferation; animal fat; bile acids; cytotoxicity; dietary calcium;

D O I：

10.1016/S0304-3835(97)04629-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dietary fat may promote colon cancer by increasing fatty acids (FA) and secondary bile acids (BA) in the colonic lumen. These cytotoxic surfactants can damage colonic epithelial cells and thus induce a compensatory hyperproliferation of crypt Cells. Our studies show that the hyperproliferative effect of type and amount of dietary fat is not simply due to changes in colonic FA and BA. This indicates that an additional, at present unknown, cytotoxic factor is involved. The hyperproliferative effect of dietary fat is inversely related to the amount of calcium in the diet. In rat and man, dietary calcium precipitates colonic cytotoxic surfactants and thus inhibits luminal cytotoxicity. These inhibitory effects on metabolic risk factors suggest a preventive effect of dietary calcium on colon carcinogenesis. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：75 / 83

页数：9

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