Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

被引：41

作者：

Chung, YL

Williams, A

Ritchie, D

Williams, SCR

Changani, KK

Hope, J

Bell, JD

机构：

[1] Hammersmith Hosp, Robert Steiner Magnet Resonance Unit, MRC Clin Sci Ctr, Imperial Coll Sch Med, London W12 0HS, England

[2] Inst Anim Hlth, BBSRC, Neuropathogenesis Unit, Edinburgh EH9 3JF, Midlothian, Scotland

[3] Inst Anim Hlth, MRC, Neuropathogenesis Unit, Edinburgh EH9 3JF, Midlothian, Scotland

[4] Inst Psychiat, Dept Clin Neurosci, London SE5 8AF, England

[5] Inst Anim Hlth, BBSRC, Compton Lab, Compton RG20 7NN, Berks, England

来源：

NEUROREPORT | 1999年 / 10卷 / 17期

基金：

英国医学研究理事会;

关键词：

CJD; histopathology; hamster; magnetic resonance imaging; scrapie;

D O I：

10.1097/00001756-199911260-00002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MAGNETIC resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：3471 / 3477

页数：7

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