Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes

被引：67

作者：

Li, Yanfei ^{[1
,2
]}

Shen, Dan ^{[2
]}

Tang, Xiaomei ^{[2
]}

Li, Xin ^{[2
]}

Wo, Da ^{[2
]}

Yan, Hongwei ^{[2
]}

Song, Rui ^{[2
]}

Feng, Jian ^{[2
]}

Li, Ping ^{[1
]}

Zhang, Jie ^{[1
,2
]}

Li, Jue ^{[2
]}

机构：

[1] Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China

[2] Tongji Univ, Sch Med, Shanghai 200092, Peoples R China

来源：

TOXICOLOGY LETTERS | 2014年 / 226卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Chlorogenic acid; Isoproterenol; Cardiac hypertrophy; ROS; NF-KAPPA-B; CARDIAC-HYPERTROPHY; OXIDATIVE STRESS; CARDIOMYOCYTE HYPERTROPHY; ADRENERGIC-STIMULATION; PROTECTS; EXPRESSION; APOPTOSIS; INFLAMMATION; INHIBITION;

D O I：

10.1016/j.toxlet.2014.02.016

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

Cardiac hypertrophy is an independent risk factor for cardiovascular disease and its subsequent progression to heart failure represents a major cause of morbidity and mortality in the world. CGA is an important component of Chinese herbal medicine, acting as an antioxidant, scavenging free radicals and preventing inflammation. This study found that with the pre-treatment of chlorogenic acid in Iso-induced neonatal rat myocytes, the levels of the hypertrophic markers, ANP, BNP and beta-MHC decreased. The nuclear translocation of NF-kappa B was blocked, whereas NF-kappa BIA, an inhibitor of NF-kappa B, was upregulated accordingly. And the level of the intracellular ROS was also reduced. These data reveal that chlorogenic acid may inhibit Iso-induced cardiac hypertrophy by attenuating NF-kappa B signaling pathway and suppressing ROS. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：257 / 263

页数：7

共 45 条

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GEOMETRY OF CAPILLARY NETWORKS IN HYPERTROPHIED RAT-HEART [J].