Metabonomics techniques and applications to pharmaceutical research & development

被引：277

作者：

Lindon, JC ^{[1
]}

Holmes, E ^{[1
]}

Nicholson, JK ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, London SW7 2AZ, England

来源：

PHARMACEUTICAL RESEARCH | 2006年 / 23卷 / 06期

基金：

美国国家卫生研究院;

关键词：

biomarkers; diagnostics; drug safety; metabonomics; spectroscopy;

D O I：

10.1007/s11095-006-0025-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this review, the background to the approach known as metabonomics is provided, giving a brief historical perspective and summarizing the analytical and statistical techniques used. Some of the major applications of metabonomics relevant to pharmaceutical Research & Development are then reviewed including the study of various influences on metabolism, such as diet, lifestyle, and other environmental factors. The applications of metabonomics in drug safety studies are explained with special reference to the aims and achievements of the Consortium for Metabonomic Toxicology. Next, the role that metabonomics might have in disease diagnosis and therapy monitoring is provided with some examples, and the concept of pharmacometabonomics as a way of predicting an individual's response to treatment is highlighted. Some discussion is given on the strengths and weaknesses, opportunities of, and threats to metabonomics.

引用

页码：1075 / 1088

页数：14

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