Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage

被引：156

作者：

Attur, MG

Patel, RN

Abramson, SB

Amin, AR

机构：

[1] HOSP JOINT DIS & MED CTR,DEPT RHEUMATOL,RES LAB,NEW YORK,NY 10003

[2] NYU,MED CTR,NEW YORK,NY 10016

来源：

ARTHRITIS AND RHEUMATISM | 1997年 / 40卷 / 06期

关键词：

D O I：

10.1002/art.1780400609

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To examine the effect of human interleukin-17 (IL-17) on nitric oxide (NO) production in human osteoarthritis (OA) cartilage under ex vivo conditions. Methods. OA cartilage from patients undergoing knee replacement surgery was used in explant assays to assess the effect of IL-17. NO production was measured by estimating the stable NO metabolite, nitrite, in conditioned medium. Results. IL-17 augmented the spontaneous production of nitric oxide. This augmentation was sensitive to cycloheximide and pyrrolidine dithiocarbamate, but not to dexamethasone or soluble IL-1 receptor. Conclusion. IL-17 augments nitric oxide production in OA cartilage via nuclear factor kappa B activation, but independently of IL-1 beta signaling.

引用

页码：1050 / 1053

页数：4

共 13 条

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[2]

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