Model-based neural decoding of reaching movements: A maximum likelihood approach

被引：59

作者：

Kemere, C ^{[1
]}

Shenoy, KV

Meng, TH

机构：

[1] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[2] Stanford Univ, Neurosci Program, Stanford, CA 94305 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2004年 / 51卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1109/TBME.2004.826675

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new paradigm for decoding reaching movements from the signals of an ensemble of individual neurons is presented. This new method not only provides a novel theoretical basis for the task, but also results in a significant decrease in the error of reconstructed hand trajectories. By using a model of movement as a foundation for the decoding system, we show that the number of neurons required for reconstruction of the trajectories of point-to-point reaching movements in two dimensions can be halved. Additionally, using the presented framework, other forms of neural information, specifically neural "plan" activity, can be integrated into the trajectory decoding process. The decoding paradigm presented is tested in simulation using a database of experimentally gathered center-out reaches and corresponding neural data generated from synthetic models.

引用

页码：925 / 932

页数：8

共 19 条

[1] Directional tuning profiles of motor cortical cells [J].

Amirikian, B ;

Georgopulos, AP .

NEUROSCIENCE RESEARCH, 2000, 36 (01) :73-79

[2] Learning to control a brain-machine interface for reaching and grasping by primates [J].

Carmena, JM ;

Lebedev, MA ;

Crist, RE ;

O'Doherty, JE ;

Santucci, DM ;

Dimitrov, DF ;

Patil, PG ;

Henriquez, CS ;

Nicolelis, MAL .

PLOS BIOLOGY, 2003, 1 (02) :193-208

[3] Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex [J].

Chapin, JK ;

Moxon, KA ;

Markowitz, RS ;

Nicolelis, MAL .

NATURE NEUROSCIENCE, 1999, 2 (07) :664-670

[4] Distribution of hand location in monkeys during spontaneous behavior [J].

Graziano, MSA ;

Cooke, DF ;

Taylor, CSR ;

Moore, T .

EXPERIMENTAL BRAIN RESEARCH, 2004, 155 (01) :30-36

[5] Robust neural decoding of reaching movements for prosthetic systems [J].

Kemere, C ;

Sahani, M ;

Meng, T .

PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH, 2003, 25 :2079-2082

[6] Decoding of plan and peri-movement neural signals in prosthetic systems [J].