Grape Seed Proanthocyanidin Extract Protects Against Carrageenan-Induced Lung Inflammation in Mice Through Reduction of Pro-inflammatory Markers and Chemokine Expressions

被引：43

作者：

Ahmad, Sheikh Fayaz ^{[1
]}

Zoheir, Khairy M. A. ^{[1
,2
]}

Abdel-Hamied, Hala E. ^{[3
]}

Attia, Sabry M. ^{[1
,4
]}

Bakheet, Saleh A. ^{[1
]}

Ashour, Abdelkader E. ^{[1
]}

Abd-Allah, Adel R. A. ^{[1
,4
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Riyadh, Saudi Arabia

[2] Natl Res Ctr, Dept Cell Biol, Cairo, Egypt

[3] Al Azhar Univ, Dept Pathol, Fac Med Girls, Cairo, Egypt

[4] Al Azhar Univ, Coll Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt

来源：

INFLAMMATION | 2014年 / 37卷 / 02期

关键词：

carrageenan; cytokines; grape seed proanthocyanidin extract; GITR; pleural exudate; lung; TNF-ALPHA PRODUCTION; NITRIC-OXIDE; ARTHRITIS; PLEURISY; CYTOKINE; INJURY; CELLS;

D O I：

10.1007/s10753-013-9764-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Proanthocyanidins are the most abundant phenolic compounds and have been reported to exert anti-inflammatory actions. The aim of this study was to investigate the effects of grape seed proanthocyanidin extract (GSPE) in a mouse model of carrageenan-induced pleurisy. Following the induction of pleurisy using lambda-carrageenan (Cg, 1 %), GSPE (25, 50 and 100 mg/kg) was administered per-oral (p.o.), and the glucocorticoid-induced tumour necrosis factor receptor (GITR), IL-17A expressing cells and other markers, such as cytokines (Th1/Th2 and Th17), were studied. We evaluate the effects of GSPE on the mRNA expression of pro-inflammatory and anti-inflammatory mediators. The results illustrated that the cell numbers of IL-17A and GITR expressing cells and the cytokine levels in Th1/Th17 cells were markedly increased in the Cg-group, whereas the cytokines produced by Th2 cells were significantly decreased in the same group. Treatment with GSPE reversed these effects. Histological examinations revealed anti-inflammatory effects of GSPE.

引用

页码：500 / 511

页数：12

共 36 条

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