Adsorption of bile acid by chitosan salts prepared with cinnamic acid and analogue compounds

被引：5

作者：

Murata, Yoshifumi ^{[1
]}

Nagaki, Kumiko ^{[1
]}

Kofuji, Kyouko ^{[1
]}

Sanae, Fujiko ^{[1
]}

Kontani, Hitoshi ^{[1
]}

Kawashima, Susumu ^{[1
]}

机构：

[1] Hokuriku Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201181, Japan

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2006年 / 17卷 / 07期

关键词：

chitosan; cinnamic acid; bile acid adsorption; lifestyle-related disease;

D O I：

10.1163/156856206777656517

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

A chitosan (CS) powder treated with cinnamic acid and an analogue compound (CN) was prepared as CS-CN. Using it, bile acid adsorption by CS-CN and the release of CN were investigated in vitro. When CS-CN was soaked in a taurocholate solution, it released CN and simultaneously adsorbed the bile acid. For CS-CN prepared with cinnamic acid, the amount of CN released was 0.286 +/- 0.001 mmol/g CS-CN; the amount of taurocholate adsorbed was 0.284 +/- 0.003 mmol/g CS-CN. These two functions were recognized on alginate or pectin gel beads containing CS-CN. The amount of released CN was altered extensively by the species of CN used for gel-bead preparation. Results suggest that CS-CN is a candidate for complementary medicine to prevent lifestyle-related diseases.

引用

页码：781 / 789

页数：9

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