Growth differentiation factor-9 is required during early ovarian folliculogenesis

被引:1025
作者
Dong, JW
Albertini, DF
Nishimori, K
Kumar, TR
Lu, NF
Matzuk, MM
机构
[1] BAYLOR COLL MED,DEPT PATHOL,HOUSTON,TX 77030
[2] BAYLOR COLL MED,DEPT CELL BIOL,HOUSTON,TX 77030
[3] BAYLOR COLL MED,DEPT MOL & HUMAN GENET,HOUSTON,TX 77030
[4] TUFTS UNIV,SCH MED,DEPT ANAT & CELLULAR BIOL,BOSTON,MA 02111
关键词
D O I
10.1038/383531a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
GROWTH factors synthesized by ovarian somatic cells directly affect oocyte growth and function(1-6), but it is unclear whether oocyte-secreted factors(6-9) play a reciprocal role in modulating somatic cell functions in vivo. During the functional analysis of members of the transforming growth factor-beta superfamily in mouse development(10-15), we have uncovered a new family member, growth differentiation factor-9 (GDF-9), which is required for ovarian folliculogenesis. GDF-9 messenger RNA is synthesized only in the oocyte from the primary one-layer follicle stage until after ovulation(16,17). Here we analyse ovaries from GDF-9-deficient female mice and demonstrate that primordial and primary one-layer follicles can be formed, but there is a block in follicular development beyond the primary one-layer follicle stage which leads to complete infertility. Oocyte growth and zona pellucida formation proceed normally, but other aspects of oocyte differentiation are compromised. Thus, GDF-9 is the first oocyte-derived growth factor required for somatic cell function in vivo.
引用
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页码:531 / 535
页数:5
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