Visualizing the immune response to pathogens

被引：13

作者：

Srinivasan, A ^{[1
]}

McSorley, SJ ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Med, Div Immunol, Farmington, CT 06030 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 04期

关键词：

D O I：

10.1016/j.coi.2004.05.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Advances in immune visualization have enabled the physical tracking of immune responses in vivo. The adaptation of such technology to models of infectious disease holds the promise of a more detailed analysis of host-pathogen interactions in a natural setting. However, the visualization of pathogen-specific immune responses in vivo confronts challenges that are inherent to the study of infectious disease systems. Recent attempts to track pathogen-specific immune responses in vivo validate the usefulness and underline the complexity of this experimental strategy.

引用

页码：494 / 498

页数：5

共 58 条

[1] Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin [J].

Agrawal, A ;

Lingappa, J ;

Leppla, SH ;

Agrawal, S ;

Jabbar, A ;

Quinn, C ;

Pulendran, B .

NATURE, 2003, 424 (6946) :329-334

[2]

[Anonymous], 1987, The pathogenesis of infectious diseases

[3] Programmed contraction of CD8+ T cells after infection [J].

Badovinac, VP ;

Porter, BB ;

Harty, JT .

NATURE IMMUNOLOGY, 2002, 3 (07) :619-626

[4] Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4+ T cells [J].

Bajénoff, M ;

Wurtz, O ;

Guerder, S .

JOURNAL OF IMMUNOLOGY, 2002, 168 (04) :1723-1729

[5] A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity [J].

Belkaid, Y ;

Mendez, S ;

Lira, R ;

Kadambi, N ;

Milon, G ;

Sacks, D .

JOURNAL OF IMMUNOLOGY, 2000, 165 (02) :969-977

[6] CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major [J].

Belkaid, Y ;

Von Stebut, E ;

Mendez, S ;

Lira, R ;

Caler, E ;

Bertholet, S ;

Udey, MC ;

Sacks, D .

JOURNAL OF IMMUNOLOGY, 2002, 168 (08) :3992-4000

[7] Estimating the precursor frequency of naive antigen-specific CD8 T cells [J].

Blattman, JN ;

Antia, R ;

Sourdive, DJD ;

Wang, XC ;

Kaech, SM ;

Murali-Krishna, K ;

Altman, JD ;

Ahmed, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :657-664

[8] The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms [J].

Boncristiano, M ;

Paccani, SR ;

Barone, S ;

Ulivieri, C ;

Patrussi, L ;

Ilver, D ;

Amedei, A ;

D'Elios, MM ;

Telford, JL ;

Baldari, CT .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) :1887-1897

[9] Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes [J].

Boulton, IC ;

Gray-Owen, SD .

NATURE IMMUNOLOGY, 2002, 3 (03) :229-236

[10] Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes [J].

Bousso, P ;

Robey, E .

NATURE IMMUNOLOGY, 2003, 4 (06) :579-585

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