Blinded by the light

被引：16

作者：

Jacobson, SG ^{[1
]}

McInnes, RR

机构：

[1] Univ Penn, Scheie Eye Inst, Dept Ophthalmol, Philadelphia, PA 19104 USA

[2] Hosp Sick Children, Res Inst, Program Dev, Toronto, ON M5G 1X8, Canada

[3] Hosp Sick Children, Res Inst, Dept Genet, Toronto, ON M5G 1X8, Canada

来源：

NATURE GENETICS | 2002年 / 32卷 / 02期

关键词：

D O I：

10.1038/ng1002-215

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Excessive exposure to visible light damages the vertebrate retina. New work demonstrates that two different pathways, a bright-light pathway and a low-light dependent pathway, mediate light-induced retinal death. Although both pathways are initiated by excessive activation of the photopigment rhodopsin, they differ in that only the bright-light pathway is AP-1-dependent and only the low-light pathway is dependent on phototransduction.

引用

页码：215 / 216

页数：2

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