Nematode spliced leaders - Ubiquity, evolution and utility

被引：101

作者：

Blaxter, M ^{[1
]}

Liu, L ^{[1
]}

机构：

[1] HARVARD UNIV, BETH ISRAEL HOSP, SCH MED, DIV INFECT DIS, BOSTON, MA 02215 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1996年 / 26卷 / 10期

基金：

英国惠康基金;

关键词：

nematode; spliced leader; trans-splicing; evolution; 5S RIBOSOMAL-RNA; CAENORHABDITIS-ELEGANS; C-ELEGANS; PARASITIC NEMATODE; BRUGIA-MALAYI; MESSENGER-RNAS; PREMESSENGER RNA; INFECTIVE LARVAE; TOXOCARA-CANIS; SEQUENCE;

D O I：

10.1016/S0020-7519(96)00060-4

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Most nematode messenger RNAs (mRNAs) have at their 5' end a common 22 nucleotide leader sequence, the trans-spliced leader or SL1. The presence of this leader on some but not all mRNAs raises several questions: What is the role of the spliced leader in mRNA maturation, stability and translation? Why do some genes have a spliced leader and others not? What is the evolutionary origin of this trans-splicing mechanism? Recently, additional trans-spliced leaders (SL2, 3, 4, 5) have been described. What role do these variants play in nematode gene expression? While definitive answers to these questions remain elusive, it is clear that the spliced leader will significantly facilitate the cloning and sequence analysis of most nematode mRNAs. Copyright (C) 1996 Australian Society for Parasitology. Published by Elsevier Science Ltd.

引用

页码：1025 / 1033

页数：9

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