Silica-supported sodium hydrogen sulfate and Amberlyst-15:: Two efficient heterogeneous catalysts for single-step synthesis of 4(3H)-quinazolinones from anthranilic acid, ortho esters, and amines under solvent free conditions

被引：48

作者：

Das, B ^{[1
]}

Banerjee, J ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

CHEMISTRY LETTERS | 2004年 / 33卷 / 08期

关键词：

D O I：

10.1246/cl.2004.960

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The single step synthesis of 4(3H)-quinazolinones has been carried out efficiently by coupling of the three components, anthranilic acid, ortho esters, and amines in the presence of silica-supported sodium hydrogen sulfate (NaHSO4.SiO2) or Amberlyst-15 as a heterogeneous catalyst. The reaction occurred within a few minutes under solvent free conditions to afford the products in excellent yields. One of the catalysts, Amberlyst-15 can be recovered and recycled.

引用

页码：960 / 961

页数：2

共 18 条

[1] AN ANTIMALARIAL ALKALOID FROM HYDRANGEA .2. ISOLATION [J].

ABLONDI, F ;

GORDON, S ;

MORTON, J ;

WILLIAMS, JH .

JOURNAL OF ORGANIC CHEMISTRY, 1952, 17 (01) :14-18

[2]

[Anonymous], CHEM PHARM B

[3] Selective monoacetylation of unsymmetrical diols catalyzed by silica gel-supported sodium hydrogen sulfate [J].

Breton, GW .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (25) :8952-8954

[4]

Connolly DJ, 2001, SYNLETT, P1707

[5]

Gueyrard D, 2000, HETEROCYCLES, V52, P827

[6] SHAN,CHANG, A CHINESE ANTIMALARIAL HERB [J].

JANG, CS ;

FU, FY ;

WANG, CY ;

HUANG, KC ;

LU, G ;

CHOU, TC .

SCIENCE, 1946, 103 (2663) :59-59

[7] IMINOKETENE CYCLOADDITION .2. TOTAL SYNTHESES OF ARBORINE, GLYCOSMININE, AND RUTECARPINE BY CONDENSATION OF IMINOKETENE WITH AMIDES [J].

KAMETANI, T ;

VANLOC, C ;

HIGA, T ;

KOIZUMI, M ;

IHARA, M ;

FUKUMOTO, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (07) :2306-2309

[8] Catalytic asymmetric synthesis of febrifugine and isofebrifugine [J].

Kobayashi, S ;

Ueno, M ;

Suzuki, R ;

Ishitani, H .

TETRAHEDRON LETTERS, 1999, 40 (11) :2175-2178

[9] AN ALKALOID WITH HIGH ANTIMALARIAL ACTIVITY FROM DICHROA-FEBRIFUGA [J].

KOEPFLI, JB ;

MEAD, JF ;

BROCKMAN, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1947, 69 (07) :1837-1837

[10]

KUROGI Y, 1996, J MED CHEM, V39, P1443

← 1 2 →