Protection of cattle against Fasciola hepatica infection by vaccination with glutathione S-transferase

被引：92

作者：

Morrison, CA

Colin, T

Sexton, JL

Bowen, F

Wicker, J

Friedel, T

Spithill, TW

机构：

[1] VICTORIAN INST ANIM SCI,ATTWOOD,VIC 3049,AUSTRALIA

[2] CIBA ANIM HLTH RES,KEMPS CREEK,NSW 2171,AUSTRALIA

来源：

VACCINE | 1996年 / 14卷 / 17-18期

关键词：

Fasciola; glutathione S-transferase; vaccine;

D O I：

10.1016/S0264-410X(96)00147-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glutathione S-transferase (GST) from the liver fluke Fasciola hepatica was assessed as a vaccine immunogen in cattle in a number of immunological adjuvants. Significant reductions in fluke burdens (49-69%) were only observed in cattle vaccinated with GST in Quil A/squalene Montanide(R) (SM) and PLG microspheres in SM but there was no correlation between anti-GST IgG titres and protection. In separate experiments, animals vaccinated with GST in Quil A/SM were still significantly protected (48%, P<0.05) 6 months after boosting and no significant differences in protection were seen when the metacercarial challenge was given over 1 month instead of as a single bolus. Inhibition of GST enzyme activity in vitro by cattle antisera did not correlate with reduced fluke burdens. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：1603 / 1612

页数：10

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