A potential role for cell-based therapeutics in the treatment of intervertebral disc herniation

被引:54
作者
Ganey, TM [1 ]
Meisel, HJ [1 ]
机构
[1] Bergmannstrost Klin, Halle An Der Saale, Germany
关键词
spine; intervertebral disc; intervertebral disc degeneration; cell-based therapeutics; tissue engineering;
D O I
10.1007/s00586-002-0494-7
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Lower back pain and disc degeneration negatively affect quality of life and impose an enormous financial burden. An extensive body of scientific work has evolved that characterizes the disc, demonstrating spinal anatomy and morphology that contribute to risk and likely promote failure. Ultimately, matrix failure is responsible for mechanical failure, which in turn results in spinal compromise anatomically and subsequent pain. One intervening approach to breaking this sequence has been to repopulate the anatomy with autologous disc chondrocytes - cells capable of restoring the matrix and retaining the mechanical balance by which the disc functions. This strategy has been implemented both in patients and in animal models, and early results, although preliminary, support the premise as a positive approach.
引用
收藏
页码:S206 / S214
页数:9
相关论文
共 25 条
[1]
An allele of COL9A2 associated with intervertebral disc disease [J].
Annunen, S ;
Paassilta, P ;
Lohiniva, J ;
Perälä, M ;
Pihlajamaa, T ;
Karppinen, J ;
Tervonen, O ;
Kröger, H ;
Lähde, S ;
Vanharanta, H ;
Ryhänen, L ;
Göring, HHH ;
Ott, J ;
Prockop, DJ ;
Ala-Kokko, L .
SCIENCE, 1999, 285 (5426) :409-412
[2]
Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures [J].
Baer, AE ;
Wang, JY ;
Kraus, VB ;
Setton, LA .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2001, 19 (01) :2-10
[3]
The pathophysiology of the intervertebral disc [J].
Bibby, SRS ;
Jones, DA ;
Lee, RB ;
Yu, J ;
Urban, JPG .
JOINT BONE SPINE, 2001, 68 (06) :537-542
[4]
ABNORMAL MAGNETIC-RESONANCE SCANS OF THE CERVICAL-SPINE IN ASYMPTOMATIC SUBJECTS - A PROSPECTIVE INVESTIGATION [J].
BODEN, SD ;
MCCOWIN, PR ;
DAVIS, DO ;
DINA, TS ;
MARK, AS ;
WIESEL, S .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1990, 72A (08) :1178-1184
[5]
Doers T.M., 1999, CURR OPIN ORTHOP, V10, P117
[6]
FRANK C, 1997, RECONSTRUCTION KNEE, P7
[7]
GELBERMAN R, 1998, INJURY REPAIR MUSCUL, P5
[8]
GHOSH P, 1977, CLIN ORTHOP RELAT R, V129, P124
[9]
The sand rat model for disc degeneration: Radiologic characterization of age-related changes - Cross-sectional and prospective analyses [J].
Gruber, HE ;
Johnson, T ;
Norton, HJ ;
Hanley, EN .
SPINE, 2002, 27 (03) :230-234
[10]
Does long-term compressive loading on the intervertebral disc cause degeneration? [J].
Hutton, WC ;
Ganey, TM ;
Elmer, WA ;
Kozlowska, E ;
Ugbo, JL ;
Doh, ES ;
Whitesides, TE .
SPINE, 2000, 25 (23) :2993-3004