Biodegradable polymeric nanospheres formed by temperature-induced phase transition in a mixture of poly(lactide-co-glycolide) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer

被引：35

作者：

Lee, KE ^{[1
]}

Kim, BK ^{[1
]}

Yuk, SH ^{[1
]}

机构：

[1] Hannam Univ, Dept Polymer Sci & Engn, Daedeog Ku, Taejon 306791, South Korea

来源：

BIOMACROMOLECULES | 2002年 / 3卷 / 05期

关键词：

D O I：

10.1021/bm020066h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mixture of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer (F-127) and PLGA (poly(lactide-co-gycolide)) forms a liquid state above their phase transition temperatures, and the phase-separated state is induced by decreasing the temperature below the phase transition temperature. On the basis of the temperature-induced phase transition behavior in the mixture of F-127 and PLGA, a novel method for the preparation of drug-loaded PLGA nanospheres was designed and characterized by measuring the loading amount, the encapsulation efficiency, and the drug release pattern. Paclitaxel, used as a potent anticancer drug, was selected as a model drug.

引用

页码：1115 / 1119

页数：5

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