Near-infrared spectroscopy for monitoring muscle oxygenation

被引:227
作者
Boushel, R
Piantadosi, CA
机构
[1] Bispebjerg Hosp, Dept Rheumatol, Sports Med Res Unit, DK-2400 Copenhagen NV, Denmark
[2] Duke Univ, Med Ctr, Dept Med, Div Pulm & Crit Care Med, Durham, NC 27710 USA
来源
ACTA PHYSIOLOGICA SCANDINAVICA | 2000年 / 168卷 / 04期
关键词
blood flow; muscle oxygenation; near infrared;
D O I
10.1046/j.1365-201x.2000.00713.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Near-infrared spectroscopy (NIRS) is a non-invasive method for monitoring oxygen availability and utilization by the tissues. In intact skeletal muscle, NIRS allows semi-quantitative measurements of haemoglobin plus myoglobin oxygenation (tissue O-2 stores) and the haemoglobin volume. Specialized algorithms allow assessment of the oxidation-reduction (redox) state of the copper moiety (CuA) of mitochondrial cytochrome c oxidase and, with the use of specific tracers, accurate assessment of regional blood flow. NIRS has demonstrated utility for monitoring changes in muscle oxygenation and blood flow during submaximal and maximal exercise and under pathophysiological conditions including cardiovascular disease and sepsis. During work, the extent to which skeletal muscles deoxygenate varies according to the type of muscle, type of exercise and blood flow response. In some instances, a strong concordance is demonstrated between the fall in O-2 stores with incremental work and a decrease in CuA oxidation state. Under some pathological conditions, however, the changes in O-2 stores and redox state may diverge substantially.
引用
收藏
页码:615 / 622
页数:8
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