Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages

被引：56

作者：

Cutone, Antimo ^{[1
]}

Frioni, Alessandra ^{[1
]}

Berlutti, Francesca ^{[1
]}

Valenti, Piera ^{[1
]}

Musci, Giovanni ^{[2
]}

di Patti, Maria Carmela Bonaccorsi ^{[3
]}

机构：

[1] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy

[2] Univ Molise, Dept Biosci & Terr, Pesche, IS, Italy

[3] Univ Roma La Sapienza, Dept Biochem Sci, I-00185 Rome, Italy

来源：

BIOMETALS | 2014年 / 27卷 / 05期

关键词：

Ferroportin; Lactoferrin; Iron; Inflammation; Interleukin-6; CERULOPLASMIN SYNTHESIS; HEPCIDIN; EXPRESSION; CELLS; INDUCTION; TRANSPORT; EFFLUX; GAMMA;

D O I：

10.1007/s10534-014-9742-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up- or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system. Ferroportin is a key player in maintenance of correct iron homeostasis, because it is the only known mammalian cellular iron exporter. In this work we show that incubation of THP-1 monocytes/macrophages with lactoferrin prevents the LPS-induced decrease of ferroportin by reducing secretion of IL-6.

引用

页码：807 / 813

页数：7

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