Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation?

被引：36

作者：

Glabe, C ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 02期

关键词：

D O I：

10.1038/72215

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Much recent Alzheimer disease research has focused on the mechanism by which amyloid precursor protein is processed to form amyloid β-peptide. Now, a new study suggests that improper clearance of amyloid β-peptide may play just as large a part as amyloid β-peptide production in amyloid deposition (143–150).

引用

页码：133 / 134

页数：2

共 16 条

[1]

BURDICK D, 1992, J BIOL CHEM, V267, P546

[2]

Neuron loss in APP transgenic mice [J].

Calhoun, ME ;

Wiederhold, KH ;

Abramowski, D ;

Phinney, AL ;

Probst, A ;

Sturchler-Pierrat, C ;

Staufenbiel, M ;

Sommer, B ;

Jucker, M .

NATURE, 1998, 395 (6704) :755-756

[3]

Irizarry MC, 1997, J NEUROSCI, V17, P7053

[4]

Identification of the major Aβ1-42-degrading catabolic pathway in brain parenchyma:: Suppression leads to biochemical and pathological deposition [J].

Iwata, N ;

Tsubuki, S ;

Takaki, Y ;

Watanabe, K ;

Sekiguchi, M ;

Hosoki, E ;

Kawashima-Morishima, M ;

Lee, HJ ;

Hama, E ;

Sekine-Aizawa, Y ;

Saido, TC .

NATURE MEDICINE, 2000, 6 (02) :143-150

[5]

INTRACELLULAR ACCUMULATION AND RESISTANCE TO DEGRADATION OF THE ALZHEIMER AMYLOID A4/BETA-PROTEIN [J].

KNAUER, MF ;

SOREGHAN, B ;

BURDICK, D ;

KOSMOSKI, J ;

GLABE, CG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) :7437-7441

[6]

A detergent-insoluble membrane compartment contains Aβ in vivo [J].

Lee, SJ ;

Liyanage, U ;

Bickel, PE ;

Xia, WM ;

Lansbury, PT ;

Kosik, KS .

NATURE MEDICINE, 1998, 4 (06) :730-734

[7]

The presence of amyloid β-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells [J].

Morishima-Kawashima, M ;

Ihara, Y .

BIOCHEMISTRY, 1998, 37 (44) :15247-15253

[8]

NORDSTEDT C, 1994, J BIOL CHEM, V269, P30773

[9]

Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse [J].

Schenk, D ;

Barbour, R ;

Dunn, W ;

Gordon, G ;

Grajeda, H ;

Guido, T ;

Hu, K ;

Huang, JP ;

Johnson-Wood, K ;

Khan, K ;

Kholodenko, D ;

Lee, M ;

Liao, ZM ;

Lieberburg, I ;

Motter, R ;

Mutter, L ;

Soriano, F ;

Shopp, G ;

Vasquez, N ;

Vandevert, C ;

Walker, S ;

Wogulis, M ;

Yednock, T ;

Games, D ;

Seubert, P .

NATURE, 1999, 400 (6740) :173-177

[10]

The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease [J].

Selkoe, DJ .

TRENDS IN CELL BIOLOGY, 1998, 8 (11) :447-453

← 1 2 →