Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis

被引：248

作者：

Brown, Andrew J. ^{[2
]}

Jessup, Wendy ^{[1
]}

机构：

[1] Univ New S Wales, Ctr Vasc Res, Sch Med Sci, Sydney, NSW 2052, Australia

[2] Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia

来源：

MOLECULAR ASPECTS OF MEDICINE | 2009年 / 30卷 / 03期

关键词：

7-Ketocholesterol; 24(S); 25-Epoxycholesterol; Efflux; LXR; Oxidised LDL; SREBP; LOW-DENSITY-LIPOPROTEIN; MACROPHAGE FOAM CELLS; APOLIPOPROTEIN-A-I; HUMAN ATHEROSCLEROTIC LESIONS; LIPID-PROTEIN INTERACTIONS; LIVER-X-RECEPTOR; STEROL; 27-HYDROXYLASE; HUMAN-PLASMA; ENDOPLASMIC-RETICULUM; OXIDATION-PRODUCTS;

D O I：

10.1016/j.mam.2009.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxysterols are structurally identical to cholesterol, but with one or more additional oxygen containing functional groups (such as alcohol, carbonyl or epoxide groups). The wide array of oxysterols encountered in human health and disease vary in their origin (either enzymic or non-enzymic), and their putative effects and/or function(s). Some are thought to be damaging, whereas others may play important physiological roles, including in the regulation of cholesterol homeostasis. In this review, we will concentrate on the major cellular oxysterols. We summarise their location, generation, metabolism and elimination, as well as providing insights into the latest research into their regulatory roles in cholesterol homeostasis. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：111 / 122

页数：12

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