Epitopes involved in antibody-mediated protection from Ebola virus

被引：376

作者：

Wilson, JA ^{[1
]}

Hevey, M ^{[1
]}

Bakken, R ^{[1
]}

Guest, S ^{[1
]}

Bray, M ^{[1
]}

Schmaljohn, AL ^{[1
]}

Hart, MK ^{[1
]}

机构：

[1] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, Frederick, MD 21702 USA

来源：

SCIENCE | 2000年 / 287卷 / 5458期

关键词：

D O I：

10.1126/science.287.5458.1664

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To determine the ability of antibodies to provide protection from Ebola viruses, monoclonal antibodies (mAbs) to the Ebola glycoprotein were generated and evaluated for efficacy. We identified several protective mAbs directed toward five unique epitopes on Ebola glycoprotein. One of the epitopes is conserved among all Ebola viruses that are known to be pathogenic for humans. Some protective mAbs were also effective therapeutically when administered to mice 2 days after exposure to Lethal Ebola virus. The identification of protective mAbs has important implications for developing vaccines and therapies for Ebola virus.

引用

页码：1664 / 1666

页数：3

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