Implication of p53 and caspase-3 in kainic acid but not in N-methyl-D-aspartic acid-induced apoptosis in organotypic hippocampal mouse cultures

被引：13

作者：

Djebaïli, M

De Bock, F

Baille, V

Bockaert, J

Rondouin, G

机构：

[1] CCIPE, CNRS, UPR 9023, F-34094 Montpellier 5, France

[2] Lab Neurotoxicol CRSSA, F-38702 La Tronche, France

来源：

NEUROSCIENCE LETTERS | 2002年 / 327卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

p53; caspase-3; neuronal death; excitotoxicity; organotypic cultures; hippocampus;

D O I：

10.1016/S0304-3940(02)00137-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apoptotic death is known to be an active process requiring the activation of several apoptotic proteins. Depending on the tissue studied and the stimulus used, these processes are distinct. In this work, we studied if there is a putative implication of the p53 and the caspase-3 proteins in kainic acid (KA) and N-methyl-D-aspartic acid (NMDA)-induced apoptosis in organotypic cultures and if there is any relationship between their respective expressions. We found that KA and NMDA both induce apoptosis but only KA-induced apoptosis is p53- and caspase-3-dependent. This demonstrates that KA and NMDA induce apoptosis following different intracellular pathways. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 4

页数：4

共 19 条

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