Functional magnetic resonance imaging (fMRI) for fetal oxygenation during maternal hypoxia:: initial results

被引：22

作者：

Wedegärtner, U

Tchirikov, M

Koch, M

Adam, G

Schröder, H

机构：

[1] Univ Klinikum Hambrg Eppendorf, Radiol Klin, Abt Diagnost & Intervent Radiol, Klin & Poliklin Radiol, D-20246 Hamburg, Germany

[2] Univ Klinikum Hambrg Eppendorf, Klin & Poliklin Frauenheilkunde, Abt Expt Gyankol Univ Frauenklin, D-20246 Hamburg, Germany

[3] Univ Klinikum Hambrg Eppendorf, Neurol Klin & Poliklin, D-20246 Hamburg, Germany

来源：

ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN | 2002年 / 174卷 / 06期

关键词：

BOLD; fMRI; fetus; lamb; acute hypoxia; sheep;

D O I：

10.1055/s-2002-32222

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To investigate the potential of fMRI to measure changes in fetal tissue oxygenation during acute maternal hypoxia in fetal lambs. Material and Methods: Two ewes carrying singleton fetuses (gestational age 125 and 131 days) underwent MR imaging under inhalation anesthesia. BOLD imaging of the fetal brain, liver and myocardium was performed during acute maternal hypoxia (oxygen replaced by N2O). Maternal oxygen saturation and heart rate were monitored by a pulse-oxymeter attached to the maternal tongue. Results: Changes of fetal tissue oxygenation during maternal hypoxia were clearly visible with BOLD MRI. Signal intensity decreases were more distinct in liver and heart (similar to40%) from control than in the fetal brain (similar to10%). Conclusions: fMRI is a promising diagnostic tool to determine fetal tissue oxygenation and may open new opportunities in monitoring fetal well being in high risk pregnancies complicated by utero-placentar insufficiency. Different signal changes in liver/heart and brain may reflect a centralization of the fetal blood flow.

引用

页码：700 / 703

页数：4

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